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How Leonardo da Vinci engineered the world’s most famous painting Leonardo da Vinci liked to think that he was as good at engineering as he was at painting, and though this was not actually the case (nobody was as good at engineering as he was at painting), the basis for his creativity was an enthusiasm for interweaving diverse disciplines. With a passion both playful and obsessive, he pursued innovative studies of anatomy, mechanics, art, music, optics, birds, the heart, flying machines, geology, and weaponry. He wanted to know everything there was to know about everything that could be known. By standing astride the intersection of the arts and the sciences, he became history’s most creative genius. His science informed his art. He studied human skulls, making drawings of the bones and teeth, and conveyed the skeletal agony of Saint Jerome in the Wilderness. He explored the mathematics of optics, showing how light rays enter the eye, and produced magical illusions of changing visual perspectives in The Last Supper. His greatest triumph of combining art, science, optics, and illusion was the smile of the Mona Lisa, which he started working on in 1503 and continued laboring over nearly until his death 16 years later. He dissected human faces, delineating the muscles that move the lips, and combined that knowledge with the science of how the retina processes perceptions. The result was a masterpiece that invites and responds to human interactions, making Leonardo a pioneer of virtual reality. The magic of the Mona Lisa’s smile is that it seems to react to our gaze. What is she thinking? She smiles back mysteriously. Look again. Her smile seems to flicker. We glance away, and the enigmatic smile lingers in our minds, as it does in the collective mind of humanity. In no other painting are motion and emotion, the paired touchstones of Leonardo’s art, so intertwined.

How Leonardo da Vinci Made Mona Lisa Smile - The Atlantic